تفاعل #357284

معادلة التفاعل

(2S)-oxiran-2-ylmethyl-3-nitrobenzenesulfonate

2-hydroxy-N-methylbenzamide

cesium carbonate

→

subtitled compound

المردود 91.4%

N-Methyl-2-[(2S)-oxiran-2-ylmethoxy]benzamide

المردود 91.4%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was partitioned between ethyl acetate and water
2. 2
   تجفيفThe organic phase was dried over sodium sulphate, Na2SO4
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated
5. 5
   أخرىThe residue was purified by silica gel flash chromatography (0-50% ethyl acetate in petroleum ether)

الإجراء التجريبي

A mixture of (2S)-oxiran-2-ylmethyl-3-nitrobenzenesulfonate (388.5 mg, 1.50 mmol), 2-hydroxy-N-methylbenzamide (226.5 mg, 1.50 mmol) and cesium carbonate (586 mg, 1.80 mmol) in dimethylformamide (6 mL) was kept on stirring at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The organic phase was dried over sodium sulphate, Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-50% ethyl acetate in petroleum ether) to give the subtitled compound (284 mg).

المصدر