تفاعل #357246

معادلة التفاعل

Cs2CO3

N-cyclopropyl-4-fluoro-2-hydroxybenzamide

(2S)-oxiran-2-ylmethyl3-nitrobenzenesulfonate

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subtitled compound

المردود 59.7%

N-Cyclopropyl-4-fluoro-2-(oxiran-2-ylmethoxy)benzamide

المردود 59.7%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was partitioned between ethyl acetate and water
2. 2
   تجفيفThe organic layer was dried over Na2SO4
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated
5. 5
   أخرىThe residue was purified by silica gel flash chromatography (0-30% ethylacetate in petroleum ether)

الإجراء التجريبي

A mixturte of N-cyclopropyl-4-fluoro-2-hydroxybenzamide (195 mg, 1.0 mmol), (2S)-oxiran-2-ylmethyl3-nitrobenzenesulfonate (259 mg, 1.0 mmol) and Cs2CO3 (390 mg, 1.2 mmol) in DMF (5 mL) was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-30% ethylacetate in petroleum ether) to give the subtitled compound (150 mg).

المصدر