تفاعل #357205

معادلة التفاعل

solution

tert-butyl 4-(4-fluorophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

→

desired product

المردود 97.0%

tert-butyl 4-(4-fluorophenyl)piperidine-1-carboxylate

المردود 97.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered
2. 2
   غسيلthe filter cake was washed with ethanol
3. 3
   تركيزThe filtrate was concentrated

الإجراء التجريبي

A solution of Example 6B (2 g, 7.2 mmol) in ethanol (30 mL) was treated with 10% Pd/C (200 mg) and shaken at room temperature under 60 psi of H2 for 4 hours. The mixture was filtered and the filter cake was washed with ethanol. The filtrate was concentrated to provide the desired product (1.95 g, 96%). MS (CI) m/e 280 (M+H)+.

المصدر