تفاعل #357015

معادلة التفاعل

ethyl 1-(4-{[5-(aminocarbonyl)-4-(benzylamino)pyrimidin-2-yl]amino}phenyl)piperidine-4-carboxylate

sodium hydroxide

sodium hydroxide

→

1-(4-{[5-(aminocarbonyl)-4-(benzylamino)pyrimidin-2-yl]amino}phenyl)piperidine-4-carboxylic acid

المردود 51.2%

المذيبات

THF methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was cooled down to room temperature
2. 2
   ترشيحthe precipitated solid was collected by filtration
3. 3
   غسيلwashed with water and methanol
4. 4
   أخرىBy recrystallizing the resulting solid from a THF-methanol mixed solvent

الإجراء التجريبي

A 15 ml THF-methanol (1:1) solution of 750 mg of ethyl 1-(4-{[5-(aminocarbonyl)-4-(benzylamino)pyrimidin-2-yl]amino}phenyl)piperidine-4-carboxylate was mixed with 1 M sodium hydroxide aqueous solution, followed by stirring under heating at 60° C. for 1 hour. The reaction mixture was cooled down to room temperature and mixed with 1 M sodium hydroxide aqueous solution, and the precipitated solid was collected by filtration and washed with water and methanol. By recrystallizing the resulting solid from a THF-methanol mixed solvent, 361 mg of 1-(4-{[5-(aminocarbonyl)-4-(benzylamino)pyrimidin-2-yl]amino}phenyl)piperidine-4-carboxylic acid was obtained as a colorless solid.

المصدر