تفاعل #356776

معادلة التفاعل

diisobutylaluminum hydride

2-benzyloxy-5-iodobenzaldehyde

2-Benzyloxy-5-iodobenzaldehyde

potassium sodium tartrate

→

(2-Benzyloxy-5-iodophenyl)methanol

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhile cooling (
2. 2
   أخرىhighly exothermic reaction), and the reaction mixture
3. 3
   workup.STIRRINGis stirred for a further 2 h
4. 4
   أخرىAfter the separation of the phases
5. 5
   غسيلthe organic phase is washed twice with water and once with a saturated aqueous sodium chloride solution
6. 6
   تجفيفdried over sodium sulfate
7. 7
   أخرىThe solvent is evaporated in vacuo
8. 8
   أخرى31.8 g (93% of theory) of product are obtained

الإجراء التجريبي

100 ml of a 1M diisobutylaluminum hydride solution in dichloromethane are added to a solution, cooled to 0° C., of 33.98 g (100.5 mmol) of 2-benzyloxy-5-iodobenzaldehyde (Example 2A) in 200 ml of dichloromethane. After stirring at 0° C. for 2 h, a saturated potassium sodium tartrate solution is added while cooling (highly exothermic reaction), and the reaction mixture is stirred for a further 2 h. After the separation of the phases, the organic phase is washed twice with water and once with a saturated aqueous sodium chloride solution and dried over sodium sulfate. The solvent is evaporated in vacuo. 31.8 g (93% of theory) of product are obtained.

المصدر