تفاعل #356684

معادلة التفاعل

2,3-Difluorophenylacetyl chloride

5-bromo-1H-pyrrolo[2,3-b]pyridine

AlCl3

→

title compound

المردود 98.4%

1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-(2,3-difluoro-phenyl)-ethanone

المردود 98.4%

المذيبات

CH2Cl2

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAfter the addition
2. 2
   أخرىthe cooling bath was removed
3. 3
   درجة الحرارةThe reaction was cooled with ice-bath
4. 4
   workup.ADDITIONmethanol (100 ml) was added to the reaction mixture
5. 5
   درجة الحرارةwhile maintaining the temperature below 30° C
6. 6
   أخرىThe reaction mixture was evaporated
7. 7
   ترشيحThe solid was collected by vacuum filtration
8. 8
   غسيلwashed with water and hexane

الإجراء التجريبي

2,3-Difluorophenylacetyl chloride(58.1 mmol) in CH2Cl2 (150 ml)was added to a suspension of 5-bromo-1H-pyrrolo[2,3-b]pyridine (8.0 g, 40.6 mmol) and AlCl3 (46 g, 345 mmol) in CH2Cl2 (100 ml) at 0° C. After the addition, the cooling bath was removed and the reaction mixture was stirred at room temperature for 1.5 hrs. The reaction was cooled with ice-bath and methanol (100 ml) was added to the reaction mixture while maintaining the temperature below 30° C. The reaction mixture was evaporated and the residue was suspended in water. The solid was collected by vacuum filtration, washed with water and hexane to give the title compound (14.03 g) in 98% yield.

المصدر