تفاعل #356660

معادلة التفاعل

7-azaindole

AlCl3

(2,3-difluorophenyl)-acetyl chloride

→

title compound

المردود 13.0%

2-(2,3-Difluoro-phenyl)-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanone

المردود 13.0%

المذيبات

methlene chloride

methlene chloride

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with methlene chloride
2. 2
   تجفيفdried (Na2SO4)
3. 3
   تركيزconcentrated

الإجراء التجريبي

To 7-azaindole (1 g, 8.5 mmol) and AlCl3 (1.2 g, 9.0 mmol) in methlene chloride at 0° C. was added (2,3-difluorophenyl)-acetyl chloride [prepared by treating (2,3-difluoro-phenyl)-acetic acid (1.5 mg, 8.72 mmol) with oxalyl chloride (0.90 mL)] in methlene chloride. After stirring at room temperature for 2 hours, the solution was poured into ice water and extracted with methlene chloride, dried (Na2SO4), and concentrated to give 300 mg (13% yield) of title compound used without purification. LCMS Rt=3.00 minutes, MH+ 273.1, M− 271.1.

المصدر