تفاعل #355768

معادلة التفاعل

5-Acetyl-1-isopropyl-2,4-dimethylimidazole

DMA

→

title compound

المردود 13.0%

5-(3-Dimethylaminoprop-2-en-1-oyl)-1-isopropyl-2,4-dimethylimidazole

المردود 13.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux, under an atmosphere of nitrogen, for 18 hours
2. 2
   أخرىThe volatiles were evaporated in vacuo
3. 3
   أخرىThe residue was purified by flash silica chromatography DCM

الإجراء التجريبي

5-Acetyl-1-isopropyl-2,4-dimethylimidazole (Method 8; 3g, 16.5 mmol) was dissolved in a mixture DMF.DMA (100 ml) and the mixture heated under reflux, under an atmosphere of nitrogen, for 18 hours. The volatiles were evaporated in vacuo. The residue was purified by flash silica chromatography DCM:MeOH (increasing in polarity from 100:0 to 95:5) to give the title compound (510 mg, 13%) as an orange oil. NMR 1.38 (d, 6H), 2.18 (s, 3H), 2.30 (s, 3H), 2.83 (s, 3H), 3.08 (s, 3H), 4.72 (q, 1H), 5.21 (d, 1H), 7.46 (d, 1H); m/z 236

المصدر