تفاعل #3557

معادلة التفاعل

6-(2,6-dichlorophenyl)-pyrido{2,3-d]pyrimidine-2,7-diamine

2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine

isopropyl isocyanate

ammonia

→

title compound

1-[2-Amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-isopropyl-urea

المذيبات

methane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe product was purified by MPLC
2. 2
   غسيلeluting with a gradient of CHCl3 :EtOAc (1:1)
3. 3
   أخرىto afford the pure product

الإجراء التجريبي

The title compound was prepared from 0.5 g of 6-(2,6-dichlorophenyl)-pyrido{2,3-d]pyrimidine-2,7-diamine from Example 1 and 0.172 mL of isopropyl isocyanate according to Example 2. The product was purified by MPLC eluting with a gradient of CHCl3 :EtOAc (1:1) to afford the pure product; mp 184°-188° C., CIMS (1% ammonia in methane): m/z (relative intensity) 391 (MH+, 16), 393 (MH+ +2, 11), 306 (100).

المصدر