تفاعل #354957

معادلة التفاعل

methanol

3-Acetoxy-3-(N-acetylisopropylaminomethyl)-7-methanesulfonamido-3,4-dihydro-2H-1,5-benzodioxepin

methanol

sodium hydroxide

→

3-hydroxy-3-isopropylaminomethyl-7-methanesulfonamido-3,4-dihydro-2H-1,5-benzodioxepin

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture is refluxed for 3 hours
2. 2
   درجة الحرارةcooled
3. 3
   workup.ADDITIONdiluted with 400 mls
4. 4
   استخلاصextracted with ether
5. 5
   غسيلThe combined ethereal solutions are washed with water
6. 6
   تجفيفdried over anhydrous sodium sulfate
7. 7
   أخرىevaporated

الإجراء التجريبي

3-Acetoxy-3-(N-acetylisopropylaminomethyl)-7-methanesulfonamido-3,4-dihydro-2H-1,5-benzodioxepin (4.2 g., 10 millimole) in 20 ml. methanol is treated with 2 g. (50 millimoles) of sodium hydroxide in 20 ml. of methanol. The mixture is refluxed for 3 hours, cooled, and diluted with 400 mls. of water, neutralized with acid and extracted with ether. The combined ethereal solutions are washed with water, dried over anhydrous sodium sulfate, and evaporated to give 3-hydroxy-3-isopropylaminomethyl-7-methanesulfonamido-3,4-dihydro-2H-1,5-benzodioxepin.

المصدر