تفاعل #354951

معادلة التفاعل

S-methyl-N-ethylisothiourea hydriodide

3-hydroxy-3-aminomethyl-3,4-dihydro-2H-1,5-benzodioxepin

→

3-hydroxy-3-(3-ethylguanidinyl)methyl-3,4-dihydro-2H-1,5-benzodioxepin hydriodide

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solution then is evaporated to a small volume
2. 2
   workup.ADDITIONdiluted with ether

الإجراء التجريبي

A mixture of S-methyl-N-ethylisothiourea hydriodide (2.46 g., 10 millimoles), 3-hydroxy-3-aminomethyl-3,4-dihydro-2H-1,5-benzodioxepin 1.95 g. (10 millimoles) from Example 1, Step E, and 20 ml. of ethanol is refluxed for four hours. The solution then is evaporated to a small volume and diluted with ether to afford 3-hydroxy-3-(3-ethylguanidinyl)methyl-3,4-dihydro-2H-1,5-benzodioxepin hydriodide.

المصدر