تفاعل #354107

معادلة التفاعل

α-(2-methoxy-5-nitrophenyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid

hydrogen

→

title compound

α-(2-methoxy-5-aminophenyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetraammonium salt

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىfor 1 hour
2. 2
   أخرىat room temperature
3. 3
   ترشيحAfter filtration
4. 4
   أخرىthe material was further purified by chromatography (silica gel, Solvent System 5)

الإجراء التجريبي

To a solution of α-(2-methoxy-5-nitrophenyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (157 mg) (prepared by the procedure of Example 11) in water (20 ml) was added platinum oxide (20 mg). This mixture was hydrogenated (1 atmosphere hydrogen) for 1 hour at room temperature. After filtration, the material was further purified by chromatography (silica gel, Solvent System 5) to yield the title compound (141 mg) as an off-white solid, and characterized by:

المصدر