تفاعل #354106

معادلة التفاعل

α-(2-methoxy-5-nitrophenyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetramethyl ester

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title product

α-(2-methoxy-5-nitrophenyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid

المذيبات

HCl

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed under a nitrogen atmosphere for 5 hours
2. 2
   تركيزThe solution was then concentrated to dryness in vacuo
3. 3
   أخرىto leave a solid residue
4. 4
   أخرىThis was purified by chromatography (silica gel, Solvent System 6)

الإجراء التجريبي

A solution of α-(2-methoxy-5-nitrophenyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetramethyl ester (prepared by the procedure of Example 10) in concentrated HCl (5 ml, J. T. Baker ULTREX) was refluxed under a nitrogen atmosphere for 5 hours. The solution was then concentrated to dryness in vacuo to leave a solid residue. This was purified by chromatography (silica gel, Solvent System 6) to yield the title product as an off-white solid (209 mg). This material was converted to the tetrahydrochloride salt and was characterized by:

المصدر