تفاعل #353898

معادلة التفاعل

2-nitroimidazole

potassium carbonate

(S)-(+)-epichlorohydrin

→

(S)-(+)-α-(Chloromethyl)-2-nitro-1H-imidazole-1-ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for 10 minutes
2. 2
   ترشيحthen filtered while hot
3. 3
   تركيزThe filtrate is concentrated
4. 4
   درجة الحرارةcooled
5. 5
   أخرىto give a solid
6. 6
   أخرىCrystallization from ethanol and further processing
7. 7
   أخرىgives the product

الإجراء التجريبي

Alternatively, a mixture of 2-nitroimidazole, anhydrous potassium carbonate, and (S)-(+)-epichlorohydrin is refluxed for 10 minutes then filtered while hot. The filtrate is concentrated and cooled to give a solid. Crystallization from ethanol and further processing gives the product.

المصدر