تفاعل #353637

معادلة التفاعل

cyclohexane

2-(5-mercapto-1,3,4-thiadiazol-2-ylthiomethyl)saccharin

2-chloroethyldiethylamine hydrochloride

triethylamine

→

2-(5-[2-(diethylamino)ethylthio]-1,3,4-thiadiazol-2-ylthiomethyl)saccharin

المذيبات

ethyl acetate

DMF

ظروف التفاعل

الإجراء التجريبي

Following a procedure similar to that described in Example 33A, 2-(5-mercapto-1,3,4-thiadiazol-2-ylthiomethyl)saccharin is reacted with 2-chloroethyldiethylamine hydrochloride in DMF in the presence of triethylamine to give 2-(5-[2-(diethylamino)ethylthio]-1,3,4-thiadiazol-2-ylthiomethyl)saccharin, mp 93.0°-94.5° C. (from cyclohexane:ethyl acetate).

المصدر