تفاعل #353636

معادلة التفاعل

2-(5-mercapto-1,3,4-thiadiazol-2-ylthiomethyl)saccharin

1-(2-chloroethyl)piperidine hydrochloride

triethylamine

ethyl acetate

→

2-(5-[2-(1-piperidinyl)ethylthio]-1,3,4-thiadiazol-2-ylthiomethyl)saccharin

المردود 60.2%

المذيبات

DMF

ظروف التفاعل

الإجراء التجريبي

Following a procedure similar to that described above in Example 33A, 0.69 g (0.002 mol) of 2-(5-mercapto-1,3,4-thiadiazol-2-ylthiomethyl)saccharin was reacted with 0.74 g (0.004 mol) of 1-(2-chloroethyl)piperidine hydrochloride in 4 ml of DMF in the presence of 0.4 g of triethylamine to give 0.55 g (60%) of 2-(5-[2-(1-piperidinyl)ethylthio]-1,3,4-thiadiazol-2-ylthiomethyl)saccharin, mp 100.0°-101.0° C. (from ethyl acetate).

المصدر