تفاعل #351971

معادلة التفاعل

3-benzyloxy-6-hydroxymethyl-2-iodopyridine

potassium acetate

ethyl acrylate

→

solution

المردود 62.0%

Ethyl (3-benzyloxy-6-hydroxymethylpyridin-2-yl)propenoate

المردود 62.0%

المذيبات

DMF

water

ظروف التفاعل

الإجراء التجريبي

To a solution of 3-benzyloxy-6-hydroxymethyl-2-iodopyridine (1.20 g, 3.50 mmol) in DMF (6.4 ml) and water (0.32 ml) were added potassium acetate (0.83 g, 8.5 mmol) palladium acetate (32 mg, 0.14 mmol) and ethyl acrylate (1.1ml, 1.01 g, 10 mmol). The mixture was placed under nitrogen and stirred and heated at 120° C. for 1.25 h. By hplc the solution yield was 62%.

المصدر