تفاعل #351788

معادلة التفاعل

sodium bicarbonate

3,5-dimethylbenzoyl chloride

(2R,4RS)-N-(2-benzyl-4-piperidyl)trifiuoroacetamide trifluoroacetate

→

title compound

(2R,4RS)-N-[2-Benzyl-1-(3,5-dimethylbenzoyl)-4-piperidyl]trifluoroacetamid

المذيبات

toluene water

—

ice water

ظروف التفاعل

المعالجة

1. 1
   أخرىpartitioned between toluene and 1N sodium bicarbonate solution
2. 2
   غسيلThe organic phases are washed with water
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   أخرىevaporated to dryness
5. 5
   أخرىThe colourless oil is chromatographed on silica gel with ethyl acetate/hexane 1:2

الإجراء التجريبي

710 mg of solid sodium bicarbonate and 712 mg of 3,5-dimethylbenzoyl chloride are added to a stirred mixture of 1.39 g (3.44 mmol) of (2R,4RS)-N-(2-benzyl-4-piperidyl)trifiuoroacetamide trifluoroacetate and 10 ml of toluene/water (1:1) cooled in ice-water. The reaction mixture is then allowed to warm to room temperature, subsequently stirred for 2 hours and partitioned between toluene and 1N sodium bicarbonate solution. The organic phases are washed with water, dried over magnesium sulfate and evaporated to dryness. The colourless oil is chromatographed on silica gel with ethyl acetate/hexane 1:2, resulting in the title compound. This is used further without further purification.

المصدر