تفاعل #351484

معادلة التفاعل

potassium carbonate

tetrahydrothiopyran-4-one

sodium cyanide

ammonium chloride

→

4-amino-4-cyano-tetrahydrothiopyran hydrochloride salt

المذيبات

water

methanol

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture is heated
2. 2
   درجة الحرارةto reflux for 14 hours
3. 3
   استخلاصextracted with diethyl ether
4. 4
   استخلاصThe organic extract
5. 5
   تجفيفis dried (MgSO4)
6. 6
   ترشيحfiltered
7. 7
   ترشيحThe resulting precipitate is filtered off

الإجراء التجريبي

A solution of tetrahydrothiopyran-4-one (4.64 g, 40.0 mmol) in methanol (10 mL) is added to a mixture of sodium cyanide (2.0 g, 40.0 mmol) and ammonium chloride (2.36 g, 44.0 mmol) in water (8 mL). The reaction mixture is heated to reflux for 14 hours. The mixture is diluted with water, basified with potassium carbonate, and extracted with diethyl ether. The organic extract is dried (MgSO4) and filtered. The solution is acidified with hydrochloric acid saturated with methylene chloride. The resulting precipitate is filtered off providing 4-amino-4-cyano-tetrahydrothiopyran hydrochloride salt.

المصدر