تفاعل #351236

معادلة التفاعل

2-Pyridylacetonitrile

tributyltin azide

→

5-(2-Pyridylmethyl)-1H-tetrazole

المذيبات

p-dioxane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe solution was refluxed for 20 hours
2. 2
   تركيزconcentrated in vacuo
3. 3
   workup.ADDITIONtreated with gaseous HCl for over 15 minutes
4. 4
   أخرىaffording a maroon-colored precipitate that
5. 5
   أخرىwas recrystallized from ethanol

الإجراء التجريبي

2-Pyridylacetonitrile (10.0 g; 0.084 moles) was dissolved in p-dioxane (200 mL) and then treated with tributyltin azide (30.9 g; 0.093 moles) in one portion. The solution was refluxed for 20 hours, cooled to room temperature, and then concentrated in vacuo. The viscous syrup was taken up in ethyl ether and treated with gaseous HCl for over 15 minutes, affording a maroon-colored precipitate that was recrystallized from ethanol. Yield: 9.1 g (55%).

المصدر