تفاعل #350615

معادلة التفاعل

trans-4-aminomethyl-1-cyclohexane carboxylic acid

benzyl chloroformate

→

trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carboxylic acid

المذيبات

NaOH

NaOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe cold bath was removed
2. 2
   workup.STIRRINGThe thick white paste was shaken with aqueous 1M HCl (100 mL)
3. 3
   أخرىthe white solid was isolated by filtration
4. 4
   غسيلwashed with H2O
5. 5
   أخرىdried overnight in vacuo

الإجراء التجريبي

To a 0° C. solution of trans-4-aminomethyl-1-cyclohexane carboxylic acid (6.28 g, 0.04 mol) in 10% aqueous NaOH (16 mL) was added dropwise benzyl chloroformate (8.29 g, 0.049 mol) and 10% aqueous NaOH (20 mL). The cold bath was removed and the reaction mixture was stirred vigorously for one hour. The thick white paste was shaken with aqueous 1M HCl (100 mL) and the white solid was isolated by filtration, washed with H2O, and dried overnight in vacuo to give trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carboxylic acid.

المصدر