تفاعل #350563

معادلة التفاعل

5-amino-2-chloro-4-fluorophenol

2-bromopropane

potassium carbonate

→

title compound

المردود 62.0%

4-Chloro-2-fluoro-5-(1 -methylethoxy)aniline

المردود 62.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for 17 h
3. 3
   درجة الحرارةThe reaction mixture was cooled
4. 4
   ترشيحfiltered
5. 5
   أخرىThe filtrate was evaporated to dryness under reduced pressure

الإجراء التجريبي

A stirring mixture of 5-amino-2-chloro-4-fluorophenol (22.0 g, 136.19 mmol), 2-bromopropane (38.4 mL, 50.25 g, 408.57 mmol) and potassium carbonate (37.6 g, 273.0 mmol) was heated at reflux for 17 h. The reaction mixture was cooled and filtered. The filtrate was evaporated to dryness under reduced pressure. Flash chromatography yielded the title compound of Step A as a brown oil (17.2 g). 1H NMR (CDCl3): δ7.02 (d, 1H), 6.44 (d, 1H) 4.38 (q, 1H), 3.81 (br s,2H), 1.33 (d,6H). IR (cm-1): 3378.4, 3475.6.

المصدر