تفاعل #3502

معادلة التفاعل

water

potassium carbonate

chloromethylpropargyl ether

N-methoxybenzamide

→

N-methoxy-N-propargyloxymethylbenzamide

المردود 91.9%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   استخلاصthe mixture was extracted with ethyl acetate
3. 3
   أخرىThe extract was dried
4. 4
   تركيزconcentrated
5. 5
   أخرىpurified by silica gel column chromatography

الإجراء التجريبي

0.6 g of N-methoxybenzamide was dissolved in 10 ml of acetonitrile, and 0.55 g of potassium carbonate and 0.42 g of chloromethylpropargyl ether were added thereto in this order. The mixture was stirred at room temperature for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.8 g of N-methoxy-N-propargyloxymethylbenzamide.

المصدر