تفاعل #3501

معادلة التفاعل

N-methoxy-2,4-dichlorobenzamide

potassium carbonate

propargyl bromide

N,N-dimethylformamide

→

propargyl N-methoxy-2,4-dichlorobenzimidate

المردود 29.8%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   استخلاصthe mixture was extracted with ethyl acetate
3. 3
   أخرىThe extract was dried
4. 4
   تركيزconcentrated
5. 5
   أخرىpurified by silica gel column chromatography

الإجراء التجريبي

1.0 g of N-methoxy-2,4-dichlorobenzamide, 0.75 g of potassium carbonate and 0.65 g of propargyl bromide were added to 10 ml of N,N-dimethylformamide, and the mixture was stirred for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.35 g of propargyl N-methoxy-2,4-dichlorobenzimidate.

المصدر