تفاعل #3497

معادلة التفاعل

trans-1,4-bis[[1-cyclohexyl-3-(4-nitrophenyl)ureido]-metyl]cyclohexane

Hydrogen

→

white crystals

المردود 106.6%

Trans-1,4-bis[[1-cyclohexyl-3-(4-aminophenyl)ureido]methyl]cyclohexane

المردود 106.6%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىsynthesized in accordance with Example 2
2. 2
   أخرىwas separated by filtration
3. 3
   تركيزthe reaction mixture was concentrated under reduced pressure
4. 4
   workup.DISSOLUTIONThe reaction mixture was dissolved in chloroform
5. 5
   workup.ADDITIONa 4N hydrochloric acid-dioxyane solution was added

الإجراء التجريبي

A 0.6 g quantity of 10% palladium carbon was added to 100 ml of a DMF solution containing 5.7 g of trans-1,4-bis[[1-cyclohexyl-3-(4-nitrophenyl)ureido]-metyl]cyclohexane synthesized in accordance with Example 2. Hydrogen was added at ordinal pressure and normal temperature for 15 hours. After completion of the reaction, palladium was separated by filtration and the reaction mixture was concentrated under reduced pressure. The reaction mixture was dissolved in chloroform and a 4N hydrochloric acid-dioxyane solution was added to provide 5.5 g (95%) of white crystals precipitated.

المصدر