تفاعل #3491

معادلة التفاعل

KOH

6-chloropurine

HCl

3,5-diacetylaniline

→

6-[(3,5-diacetylphenyl)amino]purine

المردود 90.4%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated
2. 2
   درجة الحرارةat reflux for 30 min
3. 3
   درجة الحرارةAfter cooling the mixture
4. 4
   ترشيحthe solid was filtered out
5. 5
   غسيلwashed with water
6. 6
   أخرىdried

الإجراء التجريبي

Compound No. 16: A suspension of 3,5-diacetylaniline (0.531 g) in water (10 mL) was treated with 6-chloropurine (0.464 g) and concentrated HCl (0.25 mL) and heated at reflux for 30 min. After cooling the mixture was treated with 6 mL of aqueous 1N KOH. The mixture was stirred for 10 min and the solid was filtered out, washed with water, and dried, to give 0.80 g of 6-[(3,5-diacetylphenyl)amino]purine, mp dec 340°-350° C.

المصدر