تفاعل #348403

معادلة التفاعل

7-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione

sodium hydroxide

methyl iodide

→

title compound

2-(Methylthio)-7-chloro-5-phenyl-3H-1,5-benzodiazepin-4-one

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction is evaporated
2. 2
   workup.ADDITIONdiluted with 30 ml methylene chloride
3. 3
   ترشيحfiltered through a short Florisil column
4. 4
   غسيلAfter washing the column with ethyl acetate
5. 5
   أخرىthe combined filtrates are evaporated

الإجراء التجريبي

To 3.03 g of 7-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione in a solution of 0.40 g sodium hydroxide and 15 ml of methanol is added, with stirring a solution of 1.39 g of methyl iodide in 5 ml of methanol. Stirring is continued for 1 hour, the reaction is evaporated, diluted with 30 ml methylene chloride and filtered through a short Florisil column. After washing the column with ethyl acetate, the combined filtrates are evaporated to give the title compound.

المصدر