تفاعل #3472

معادلة التفاعل

2-Cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole

methyl bromoacetate

NaH

→

[[2-cyclopropyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid methyl ester

المردود 63.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe product was purified by chromatography over silica gel eluting with 20% EtOAc/hexane

الإجراء التجريبي

2-Cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole (316 mg, 1.2 mmol) was alkylated by treating with 0.11 mL (1.2 mmol) of methyl bromoacetate and 48 mg (1.2 mmol) of 60% NaH/mineral oil in DMF as described in Example 1, Part E. The product was purified by chromatography over silica gel eluting with 20% EtOAc/hexane, to give 253 mg (63% yield) of [[2-cyclopropyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid methyl ester.

المصدر