تفاعل #346341

ord-4c6d7da272c8424aa4f0bda77fd4b31e

معادلة التفاعل

CC(=O)OCC(=O)[C@@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C)C[C@@]21C
11β-trimethylsiloxy-17α,21-diacetoxypregna-1,4-diene-3,20-dione
CC(=O)[O-].[K+]
potassium acetate
→
CC(=O)OCC(=O)C1=CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C)C[C@]12C
compound 55
CC(=O)OCC(=O)C1=CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C)C[C@]12C
11β-trimethylsiloxy-21-acetoxypregna-1,4,16-triene-3,20-dione

المتفاعلات

CC(=O)OCC(=O)[C@@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O[Si](C)(C)C)C[C@@]21C
11β-trimethylsiloxy-17α,21-diacetoxypregna-1,4-diene-3,20-dione
CC(=O)[O-].[K+]
potassium acetate

الكواشف

لا شيء

المذيبات

CN(C)C=O
dimethylformamide

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

4 g of 11β-trimethylsiloxy-17α,21-diacetoxypregna-1,4-diene-3,20-dione (from Example 30) was treated with potassium acetate and dimethylformamide exactly as described in Example 28. There was obtained 11β-trimethylsiloxy-21-acetoxypregna-1,4,16-triene-3,20-dione (compound 55).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04036831uspto-grants-1977_07