تفاعل #345720

معادلة التفاعل

7-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione

sodium hydroxide

methyl iodide

→

2-(Methylthio)-7-chloro-5-phenyl-3H-1,5-benzodiazepin-4-one

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction is then evaporated
2. 2
   ترشيحThe suspension is filtered through a short Florisil column
3. 3
   غسيلthe column is washed with ethyl acetate
4. 4
   أخرىthe combined filtrates are evaporated
5. 5
   أخرىThe residue is triturated with a minimum amount of absolute ethanol
6. 6
   ترشيحthe title compound is filtered off
7. 7
   أخرىdried

الإجراء التجريبي

To 3.03 g of 7-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione in a solution of 0.40 g of sodium hydroxide and 15 ml of methanol is added, with stirring a solution of 1.4 g of methyl iodide in 10 ml of methanol. Stirring is continued for 1 hour, the reaction is then evaporated and suspended in methylene chloride (30 ml). The suspension is filtered through a short Florisil column; the column is washed with ethyl acetate and the combined filtrates are evaporated. The residue is triturated with a minimum amount of absolute ethanol and the title compound is filtered off and dried.

المصدر