تفاعل #3452

معادلة التفاعل

1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole

NaH

methyl bromoacetate

→

[[1-[(4-fluorophenyl)methyl]-2-methyl-1H-indol-4-yl]oxy]acetic acid methyl ester

المردود 81.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe product was purified by chromatography over silica gel eluting with 20% EtOAc/hexane

الإجراء التجريبي

Using the procedure described in Example 1, Part E, 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole (881 mg, 3.45 mmol) was treated with 138 mg (3.45 mmol) of 60% NaH/mineral oil and then 0.33 mL (3.45 mmol) of methyl bromoacetate. The product was purified by chromatography over silica gel eluting with 20% EtOAc/hexane, to give 914 mg (81% yield) of [[1-[(4-fluorophenyl)methyl]-2-methyl-1H-indol-4-yl]oxy]acetic acid methyl ester, mp, 92°-98° C.

المصدر