تفاعل #344866

معادلة التفاعل

lithium diisopropylamide

2,6-difluoropyridine

N,N-dimethylethyleneurea

2-(4'-propylbicyclohexyl-4-yl)-1-iodoethane

→

2-(4'-propylbicyclohexyl-4-yl)-1-(2,6-difluoropyridine-3-yl)ethane

المذيبات

THF hexane

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىgive the pure product

الإجراء التجريبي

A solution of 0.02 mol of lithium diisopropylamide in THF/hexane (prepared analogously to Example 1) is added dropwise at 25° C. to a mixture of 0.2 mol of 2,6-difluoropyridine, 0.02 mol of N,N-dimethylethyleneurea, 0.02 mol of 2-(4'-propylbicyclohexyl-4-yl)-1-iodoethane and 25 ml of THF. Stirring for 1.5 hours and workup as described in Example 1 give the pure product.

المصدر