تفاعل #3448

معادلة التفاعل

1-[(2,6-dichlorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole

NaH

methyl bromoacetate

→

[[1-[(2,6-dichlorophenyl)methyl]-2-methyl-1H-indol-4-yl]oxy]acetic acid methyl ester

المردود 39.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe product was purified by chromatography over silica gel eluting with 20% EtOAc/hexane

الإجراء التجريبي

Using the procedure described in Example 1, Part E, 1-[(2,6-dichlorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole (862 mg, 2.8 mmol) was treated with 112 mg (2.8 mmol) of 60% NaH/mineral oil and then 0.27 mL (2.8 mmol) of methyl bromoacetate. The product was purified by chromatography over silica gel eluting with 20% EtOAc/hexane, to give 411 mg (39% yield) of [[1-[(2,6-dichlorophenyl)methyl]-2-methyl-1H-indol-4-yl]oxy]acetic acid methyl ester,-mp, 168°-169° C.

المصدر