تفاعل #344036

معادلة التفاعل

rac-3,4-dihydro-2-ethynyl-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol

1-iodonaphthalene

→

rac-3,4-dihydro-2,5,7,8-tetramethyl-2-[(1-naphthyl)ethynyl]-2H-1-benzopyran-6-ol

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىIt was isolated by chromatography over 40 fold amount of silica gel
2. 2
   أخرىThe combined clean fractions were crystallized from hexane
3. 3
   أخرىrecrystallized from petroleum ether
4. 4
   أخرىto give colorless crystals with m.p. 127°-128°

الإجراء التجريبي

rac-3,4-dihydro-2,5,7,8-tetramethyl-2-[(1-naphthyl)ethynyl]-2H-1-benzopyran-6-ol was prepared by coupling rac-3,4-dihydro-2-ethynyl-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol with 1-iodonaphthalene under the conditions described in Example 1. It was isolated by chromatography over 40 fold amount of silica gel using methylene chloride. The combined clean fractions were crystallized from hexane and recrystallized from petroleum ether to give colorless crystals with m.p. 127°-128°.

المصدر