تفاعل #343818

معادلة التفاعل

hydrogen

6-chloro-N4 -(2-pyridinylmethyl)-4,5-pyrimidinediamine

thiophene

calcium oxide

→

N4 -(2-pyridinylmethyl)-4,5-pyrimidinediamine

المردود 100.0%

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe catalyst was filtered off
2. 2
   أخرىthe filtrate was evaporated

الإجراء التجريبي

A mixture of 62.2 parts of 6-chloro-N4 -(2-pyridinylmethyl)-4,5-pyrimidinediamine, 3 parts of a solution of thiophene in methanol 4%, 20 parts of calcium oxide and 400 parts of methanol was hydrogenated at normal pressure and at 50° C. with 5 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 63.5 parts (100%) of N4 -(2-pyridinylmethyl)-4,5-pyrimidinediamine as a residue (interim. 15).

المصدر