تفاعل #343763

معادلة التفاعل

2-(pyrrol-1-yl)malonic acid diethyl ester

(-)-menthol

→

title compound

المردود 31.8%

2-(pyrrol-1-yl)malonic acid ethyl (-)-menthyl ester

المردود 31.8%

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter removal of the (-)-menthol under reduced pressure
2. 2
   أخرىthe residue was chromatographed on silica gel
3. 3
   workup.ADDITIONFractions containing the title compound
4. 4
   أخرىevaporated under reduced pressure

الإجراء التجريبي

To a mixture of 2-(pyrrol-1-yl)malonic acid diethyl ester (300.0 g) and (-)-menthol (417.0 g) was added tetraethyl titanate (10.0 g), and the resulting mixture was stirred at 110° C. for 19 hours. After removal of the (-)-menthol under reduced pressure, the residue was chromatographed on silica gel using n-hexane/ethyl acetate (50:1) as the eluent. Fractions containing the title compound were pooled and evaporated under reduced pressure to give the title compound (142.0 g, 31.8%) as a colorless oil.

المصدر