تفاعل #343462

معادلة التفاعل

Water

3-cyclopropylmethylthio-1,2,4-triazole

diethylcarbamoyl chloride

→

1-diethylcarbamoyl-3-cyclopropylmethylthio-1,2,4-triazole

المردود 83.5%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   استخلاصwas then extracted with chloroform (150 ml) two times
2. 2
   استخلاصThe chloroform extract
3. 3
   غسيلwas washed with 1N hydrochloric acid (150 ml) two times and water (200 ml) one time
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To a solution of 3-cyclopropylmethylthio-1,2,4-triazole (3.8 g) in pyridine (30 ml), diethylcarbamoyl chloride (3.4 g) was added, and the resultant mixture was allowed to stand at room temperature for 10 hours. Water (250 ml) was added to the reaction mixture, which was then extracted with chloroform (150 ml) two times. The chloroform extract was washed with 1N hydrochloric acid (150 ml) two times and water (200 ml) one time, dried over magnesium sulfate, and concentrated under reduced pressure to give 5.2 g of 1-diethylcarbamoyl-3-cyclopropylmethylthio-1,2,4-triazole (Compound No. 1). Yield, 84%. M.P. 51°-52° C.

المصدر