تفاعل #343017

معادلة التفاعل

sulfonyl isocyanate

2-[2-(acetyloxy)ethyl]benzenesulfonyl isocyanate

2-amino-4,6-dimethoxypyrimidine

→

2-[2-(acetyloxy)ethyl]-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide

المردود 54.8%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   ترشيحFiltration of the insoluble solids
2. 2
   غسيلwashing with 1-chlorobutane
3. 3
   أخرىby drying

الإجراء التجريبي

To a stirred solution of 2.3 g of the sulfonyl isocyanate from Example 7 in 25 ml dry acetonitrile was added 1.2 g of 2-amino-4,6-dimethoxypyrimidine. The reaction mixture was warmed to 50° C. for 11/4 hour and then stirred at room temperature for 2 days. Filtration of the insoluble solids and washing with 1-chlorobutane followed by drying afforded 1.8 g of 2-[2-(acetyloxy)ethyl]-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide as a light yellow solid, m.p. 160°-162° C.

المصدر