تفاعل #342095

معادلة التفاعل

N-propylamine

1,4-cyclohexanedione monoethylene ketal

oxalic acid

→

4-n-propylaminocyclohexanone ethylene ketal oxalate

المذيبات

ethanol

MeOH

isopropanol

ظروف التفاعل

المعالجة

1. 1
   workup.WAITThe mixture is hydrogenated at 3 bar for several hours
2. 2
   ترشيحfiltered on a plate
3. 3
   أخرىobtaining 274 g (95%)

الإجراء التجريبي

N-propylamine (88.5 g, 123 mL, 1.5 mol) is added to a solution of 1,4-cyclohexanedione monoethylene ketal (156 g, 1 mol) in ethanol (780 mL). 5% Pd/C (50% water) is added to the mixture. The mixture is hydrogenated at 3 bar for several hours. Once the reaction has ended, the solvent is eliminated and the residue is dissolved in isopropanol (1.560 mL). A solution of oxalic acid (132 g, 1.5 mol) in MeOH (200 mL) is added dropwise to this solution. The suspension is stirred for 30 minutes and filtered on a plate, obtaining 274 g (95%).

المصدر