تفاعل #342076

معادلة التفاعل

N-methoxymethyl-N-methylpyrrolidinium chloride

trifluoromethane sulfonic acid

→

desired product

المردود 95.4%

N-methoxymethyl-N-methylpyrrolidinium trifluoromethanesulfonate

المردود 95.4%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was reacted at room temperature for 2 hours
2. 2
   درجة الحرارةwith gradual increase of temperature
3. 3
   تركيزThe reaction mixture was concentrated
4. 4
   أخرىdried in a vacuum
5. 5
   أخرىThe residue was purified through alumina column (ICN Biomedicals. GmbH, ICN Alumina N, Act.1/eluent acetonitrile)
6. 6
   تركيزThe eluate was concentrated
7. 7
   أخرىdried in a vacuum

الإجراء التجريبي

In 116 g of dehydrated chloroform (reagent, Wako Pure Chemical Ind. Ltd.) was dissolved 24.3 g of N-methoxymethyl-N-methylpyrrolidinium chloride. To the solution was added dropwise 24.3 g of trifluoromethane sulfonic acid (reagent, Aldrich Corp.) at 5° C. over a period of 1 hour. The mixture was reacted at room temperature for 2 hours with gradual increase of temperature. The reaction mixture was concentrated and dried in a vacuum. The residue was purified through alumina column (ICN Biomedicals. GmbH, ICN Alumina N, Act.1/eluent acetonitrile). The eluate was concentrated and dried in a vacuum to obtain 39.1 g of the desired product (colorless liquid).

المصدر