تفاعل #342014

معادلة التفاعل

1-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-4,4-dimethylpentane-1,3-dione

hydrazine monohydrate

THF

→

title compound

المردود 63.4%

5′-tert-butyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H,1′H-3,3′-bipyrazole

المردود 63.4%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooled down to room temperature
2. 2
   أخرىfurther purified by prep HPLC

الإجراء التجريبي

To a suspension of 1-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-4,4-dimethylpentane-1,3-dione (555 mg, 1.20 mmol) (B) in EtOH (5.5 mL) was added hydrazine monohydrate (0.12 g, 2.4 mmol). The reaction mixture was refluxed at 90° C. for 6 hours. After cooled down to room temperature, the resulting suspension was dissolved by addition of THF (15 mL) and further purified by prep HPLC to provide 350 mg (0.761 mmol, 63%) of the title compound.

المصدر