تفاعل #342

معادلة التفاعل

O=C1NCCc2cc(Br)ccc21

NCc1ccccc1

→

O=C1NCCc2cc(NCc3cccc

المذيبات

Cc1ccccc1

ظروف التفاعل

الإجراء التجريبي

In a small MW* sealed test tube was 6-bromo-3,4-dihydroisoquinolin-1(2H)-one (50 mg, 0.22 mmol), phenylmethanamine (24.16 µl, 0.22 mmol), palladium(II) acetate (2.483 mg, 0.01 mmol), Ethylenebis(diphenylphosphine) (8.81 mg, 0.02 mmol) and sodium methoxide (13.14 mg, 0.24 mmol) in toluene (2188 µl) combined to give a orange suspension. Heated reaction to 100°C overnight. Took LCMS - No reaction, only see unreacted SM. Discarded reaction.

المصدر