تفاعل #341970

معادلة التفاعل

Sodium triacetoxyl-borohydride

5-bromo-pyridine-3-amine

3-cyclopentyloxy-4-methoxy-benzaldehyde

HOAc

→

5-bromo-N-(3-(cyclopentyloxy)-4-methoxybenzyl)pyridin-3-amine

المردود 93.0%

المذيبات

DCE

—

1,2-dichloroethtane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   غسيلThe organic phase was washed with water
3. 3
   تجفيفdried over sodium sulfate
4. 4
   أخرىThe solvent was removed by under reduced pressure

الإجراء التجريبي

Sodium triacetoxyl-borohydride (245 mg, 1.16 mmol) was added to the solution of 5-bromo-pyridine-3-amine (100 mg, 0.57 mmol) and 3-cyclopentyloxy-4-methoxy-benzaldehyde (127 mg, 0.57 mmol) in 10 ml of 1,2-dichloroethtane (DCE), of HOAc (66 μL, 2 eq. 1.16 mmol) was added, the mixture was stirred overnight at room temperature, followed by addition of 15 ml of DCE. The organic phase was washed with water, and dried over sodium sulfate. The solvent was removed by under reduced pressure to give 200 mg of crude 5-bromo-N-(3-(cyclopentyloxy)-4-methoxybenzyl)pyridin-3-amine, which was used for the next step without further purification.

المصدر