تفاعل #341083

ord-fa55a0698aad45cb8cb95f2e9d3df2f7

معادلة التفاعل

CCN(CC)CCS
2-diethylamino-ethanethiol
CC(=O)N1CCC(N(C(=O)Nc2ncc(SC#N)s2)C2CCCCC2)CC1
1-(1-acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol
→
CCN(CC)CCSc1cnc(NC(=O)N(C2CCCCC2)C2CCN(C(C)=O)CC2)s1
1-(1-Acetyl-piperidin-4-yl)-1-cyclohexyl-3-[5-(2-diethylamino-ethylsulfanyl)-thiazol-2-yl]-urea

المتفاعلات

CCN(CC)CCS
2-diethylamino-ethanethiol
—
( I )
CC(=O)N1CCC(N(C(=O)Nc2ncc(SC#N)s2)C2CCCCC2)CC1
1-(1-acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىPrepared

الإجراء التجريبي

Prepared as described in general procedures (H) and (I) using 1-(1-acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and 2-diethylamino-ethanethiol

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07872139B2uspto-grants-2011_01