تفاعل #341076

ord-a5db4bad127b4cc2b6e87f867b12903f

معادلة التفاعل

CCOC(=O)C(C)Sc1cnc(NC(=O)N(C2CCC2)[C@H]2CC[C@H](C)CC2)s1
{2-[3-Cyclobutyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester
C[C@H]1CC[C@H](NC2CCC2)CC1
cyclobutyl-(trans-4-methyl-cyclohexyl)-amine
CCOC(=O)C(C)S.Nc1cncs1
5-aminothiazole 2-mercaptopropionic acid ethyl ester
→
C[C@H]1CC[C@H](N(C(=O)Nc2ncc(SCCC(=O)O)s2)C2CCC2)CC1
title compound
C[C@H]1CC[C@H](N(C(=O)Nc2ncc(SCCC(=O)O)s2)C2CCC2)CC1
3-{2-[3-Cyclobutyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid

المتفاعلات

CCOC(=O)C(C)Sc1cnc(NC(=O)N(C2CCC2)[C@H]2CC[C@H](C)CC2)s1
{2-[3-Cyclobutyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester
C[C@H]1CC[C@H](NC2CCC2)CC1
cyclobutyl-(trans-4-methyl-cyclohexyl)-amine
CCOC(=O)C(C)S.Nc1cncs1
5-aminothiazole 2-mercaptopropionic acid ethyl ester

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىHydrolysis

الإجراء التجريبي

{2-[3-Cyclobutyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester prepared as described in general procedure (A) using cyclobutyl-(trans-4-methyl-cyclohexyl)-amine and 5-aminothiazole-2-mercaptopropionic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07872139B2uspto-grants-2011_01