تفاعل #341024

معادلة التفاعل

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

pyrrolidine-3-carboxylic acid benzyl ester hydrochloride

sodium triacetoxyborohydride

→

desired product

المردود 50.0%

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid benzyl ester

المردود 50.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىPrepared

الإجراء التجريبي

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (67 mg. 0.20 mmol), pyrrolidine-3-carboxylic acid benzyl ester hydrochloride (50 mg, 0.25 mmol) and sodium triacetoxyborohydride (55 mg, 0.26 mmol) to afford 52 mg (50%) of the desired product after purification.

المصدر