تفاعل #341022

معادلة التفاعل

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

glycine tert-butyl ester hydrochloride

sodium triacetoxyborohydride

→

desired product

المردود 68.8%

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid tert-butyl ester

المردود 68.8%

ظروف التفاعل

المعالجة

1. 1
   أخرىPrepared

الإجراء التجريبي

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (67 mg. 0.20 mmol), glycine tert-butyl ester hydrochloride (50 mg, 0.30 mmol) and sodium triacetoxyborohydride (59 mg, 0.28 mmol) to afford 62 mg (68%) of the desired product after purification.

المصدر