تفاعل #341020

معادلة التفاعل

sodium triacetoxyborohydride

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

2-piperazinone

acetic acid

→

desired product

المردود 40.0%

1,1-Dicyclohexyl-3-[5-(3-oxo-piperazin-1-ylmethyl)-thiazol-2-yl]-urea

المردود 40.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىPrepared

الإجراء التجريبي

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (40 mg, 0.12 mmol), 2-piperazinone (18 mg, 0.18 mmol), acetic acid (7 μL, 0.12 mmol) and sodium triacetoxyborohydride (38 mg, 0.18 mmol) to afford 20 mg (40%) of the desired product after purification.

المصدر