تفاعل #341018

معادلة التفاعل

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

pyrrolidine-2(R)-carboxylic acid benzyl ester hydrochloride

sodium triacetoxyborohydride

→

desired product

المردود 78.6%

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-2(R)-carboxylic acid benzyl ester

المردود 78.6%

ظروف التفاعل

المعالجة

1. 1
   أخرىPrepared

الإجراء التجريبي

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (75 mg. 0.223 mmol), pyrrolidine-2(R)-carboxylic acid benzyl ester hydrochloride (73 mg, 0.31 mmol) and sodium triacetoxyborohydride (71 mg, 0.335 mmol) to afford 92 mg (78%) of the desired product after purification.

المصدر