تفاعل #340289

معادلة التفاعل

2-(2-bromo-5-fluorophenyl)-N-methoxy-N -methylcyclopropane-carboxamide

potassium hydroxide

HCl

→

title compound

2-(2-Bromo-5-fluorophenyl)cyclopropanecarboxylic acid

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe product was extracted with 5% methanol/dichloromethane (3×30 mL)
2. 2
   تجفيفdried over sodium sulfate
3. 3
   تركيزconcentrated

الإجراء التجريبي

A solution of 2-(2-bromo-5-fluorophenyl)-N-methoxy-N -methylcyclopropane-carboxamide (304 mg, 1.0 mmol), 10 M potassium hydroxide (3.5 mL, 35 mmol), and dioxane (2.5 mL) was heated at 130° C. in a sealed tube for 19 h. Upon cooling to room temperature, the reaction mixture was acidified with 3 M HCl (20 mL), and the product was extracted with 5% methanol/dichloromethane (3×30 mL). The organic fractions were combined, dried over sodium sulfate, and concentrated to afford the title compound as a white solid. MS m/z: 259 & 261 (M+1).

المصدر